2023-04-16 16:21:42
The drug “Mounjaro”, which is used to treat diabetes, has received special attention recently. As some resorted to it to lose weight, after some research concluded that its effect exceeds the effect of real estate “Ozempic” AndWegovy.
So what is “Monjaro”? How does it work? Was it approved as a drug for weight loss? How many people who used it lost weight?
A newspaper report indicated The New York Times American, that a study found that taking terzipatide – the active ingredient in “Monjaro” – led to a sharp decrease in blood sugar levels and a greater weight loss, compared to other drugs.
However, Dr. Dean Schillinger, professor of medicine and diabetes expert at the University of California, San Francisco, acknowledged the difficulty of comparing different doses of semaglutide — the active ingredient in Ozambique and Wegovi — with terzipatide, and determining how it works. Each type of these drugs.
What is “Monjaro”?
Monjaro, a weekly injectable drug, is FDA-approved to lower blood sugar in adults with type 2 diabetes, not for use in patients with type 1 diabetes. .
Monjaro is the trade name, and the scientific name is Tirzepatide.
Monjaro should be used in conjunction with diet and exercise. It has also been proven in clinical trials that the drug is useful in losing weight, but it is not currently approved as a weight loss drug by the Food and Drug Administration, according to the website. “Drugs”
Monjaro comes as a solution (liquid) in a ready-to-use pen for injection under the skin of the abdomen, thigh, or upper arm. It is usually given once a week with or without meals at any time of the day.
Your doctor will probably start you on a low dose and gradually increase your dose, no more than once every 4 weeks.
How does Monjaro work?
Monjaro lowers blood sugar levels by increasing insulin production and decreasing the amount of sugar made by the liver. It also slows the rate at which food passes through your body, making you feel fuller for longer.
Terzipatide mimics two hormones that are naturally produced in the body. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide.
Researchers believe that terzipatide may be highly effective in lowering blood sugar levels and losing weight.
How Much Weight Do Monjaro Users Lose?
Terzipatide slows stomach emptying, which makes people feel fuller for longer, said Dr. Janice Jane Huang, chief of the division of endocrinology and metabolism at the University of North Carolina School of Medicine. Terzipatide also works by blocking hunger signals in the brain, which leads to a suppression of appetite.
Research presented at an American Diabetes Association conference last summer showed that participants who took terzipatide lost up to 22.5 percent of their body weight after 72 weeks, a significant reduction almost as effective as weight-loss surgery, said Dr. Robert Gabay. Chief Scientific and Medical Officer of the Society.
Is it safe to take Monjaro for weight loss?
Monjaro has been shown to help with weight loss in obese patients, but it is not yet approved as a weight loss drug, as it is still in Phase III clinical trials in adults.
Dr. Akshaya Srikanth Bhagavathula, who studies Terzipatide, says taking Monjaro may lead to more serious side effects than Uzumbic and Wiggoi, as well as greater weight loss. People who use the drug usually experience nausea, vomiting, diarrhea, and stomach pain. In rare cases, taking the drug can lead to kidney failure, pancreatitis, hypoglycemia, and gastrointestinal bleeding.
There’s no solid research examining how terzipatide might affect people who don’t have diabetes or obesity, “We don’t have enough information to determine what risk patients (using the drug for weight loss) take,” says Dr. Schillinger.
Dr. Andrew Craftson, associate professor in the division of metabolism, endocrinology and diabetes at Michigan Medicine, said those taking the drug need close medical supervision, in part because there is a risk that a severe lack of appetite could lead to malnutrition and disordered eating. To make people anorexic… the goal is not to get rid of all hunger.”
Monjaro Dosages
inform The recommended starting dose of Monjaro is 2.5 mgIt is injected under the skin once a week. This dose is not sufficient to control blood sugar, but it is recommended to start treatment.
After 4 weeks, the dose is increased to 5 mg injected under the skin once a week.
If more blood sugar control is needed, the doctor may recommend an increase in the dose by 2.5 milligrams after at least 4 weeks of the current dose.
The maximum dose of Monjaro is 15 mg injected under the skin once a week.
What are the side effects of Monjaro?
Monjaro may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- Nausea.
- diarrhea.
- Anorexia.
- vomiting.
- constipation.
- upset stomach
Some side effects can be serious, such as:
- Stomach pain that does not go away (and may spread to the back) with or without vomiting.
- Monjaro may cause hypoglycemia (low blood sugar). Signs and symptoms of low blood sugar may include dizziness, lightheadedness, blurred vision, anxiety, irritability, mood changes, sweating, slurred speech, hunger, confusion, drowsiness, tremors, weakness, headache, fast heart rate, or feeling jittery.
Monjaro may cause thyroid C-cell tumors. Tell your doctor if you have a personal or family history of thyroid cancer or a condition called Multiple Endocrine Neoplasia (MEN) syndrome, a syndrome that causes tumors to appear in the endocrine glands.
If you experience any of the following symptoms, contact your doctor immediately:
- swelling in your neck;
- Hoarseness.
- Difficulty swallowing.
- shortness of breath.
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