2023-08-08 07:00:00
A rejuvenated Luis Miguel revolutionizes Argentina as part of his comeback with 10 concerts in Buenos Aires. Christian Garavaglia Meteored Argentina 08/08/2023 09:00 6 min
The return of Luis Miguel put Argentina in turmoil, and one of the hottest topics on TV shows and social media right now is his youthful appearance and vitality at 53.
It has been reported that, among his latest changes in fitness habits, Luis Miguel implemented a diet known as intermittent fasting, one of the three keys to the longevity formula, according to a Harvard expert.
Is it possible to reverse the biological clock and rejuvenate? The key to epigenetics
It is to this question that a group of scientists led by David Sinclair, researcher at the Harvard Medical Schoolrecently tried to answer. The team succeeded in reversing biological aging in mice and also defined some clues that could help reverse it in humans as well.
Epigenetics is one of the main explanations for the success of this scientist and his team in reversing aging. This is the study of the mechanisms that regulate the expression of genes without modifying the DNA sequence that constitutes them.
David Sinclair’s team has determined that part of the epigenetic information in cells is lost following the repair of DNA double-strand breaks. There research showed that during this repair, different chromatin-modifying proteins switch places, move to where DNA is damaged, and alter the accessibility of gene expression machinery to affected regions.
David Sinclair, Harvard Medical School.
David Sinclair’s team proposed that this epigenetic alteration of chromatin induced by the activity of DNA repair mechanisms is the primary cause of aging.
In this experiment, comparing mice in which DNA breaks were induced with ICE (epigenome changes) mice, the researchers observed that over time, the former began to show epigenetic alterations in chromatin organization. In addition, mice with altered epigenome were beginning to show signs of aging at the molecular, physiological and neurological levels.
Epigenetic aging can be reversed
However, this study made it possible to see how this aging induced in ICE mice was reversible. To do this, they were treated with gene therapy aimed at reprogramming the cells into a more youthful state. Cells can thus restore the epigenetic information they possessed in their early years. After this treatment, the mice regained their lost functionality, demonstrating that cells have the ability to reset themselves at the epigenetic level.
A possibility of rejuvenating cells and tissues which could contribute not only to delaying aging, but also to prevent or treat other age-related diseases such as diabetes or neurodegeneration. However, this is still only data obtained in mice that will need to be confirmed in humans.
Three key habits to reverse aging in men
For Sinclair, one of the fundamental keys to reversing aging in humans is to see aging as a natural process and not as a disease. In fact, to reduce our biological age, the scientist emphasizes three key habits:
Intermittent fasting: Sinclair doesn’t place too much emphasis on breakfast and opts for a fast of 16 to 18 hours. However, one should always consult a professional or nutritionist before doing so and start gradually, as the intermittent method can lead to lack of aerobic performance, loss of muscle mass, sleep disturbances, bone mineral loss, among other problems. . This method is not recommended for pregnant or breastfeeding women, or for people with eating disorders, low body fat, or diabetes. The newest “baby” volcano on Earth was formed on the 10 July: where is it?Include enough vegetables in the diet: it is essential to pay attention to what we eat on a daily basis and to ensure that our diet is balanced and healthy. For Sinclair, it is essential to include vegetables and water with every meal and to accompany other foods.Let’s take resveratrol: it is found in foods such as berries, grapes, peanuts and blackberries. This chemical may also play a key role in helping the body fight disease and rejuvenate, while promoting healthy weight loss.
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