2023-07-07 11:19:47
Japanese researchers hope to use a new drug to treat a genetic disorder that prevents teeth from growing.
animals like Hedge and some reptile species can constantly regrow their teeth. In humans, the possibilities are limited in this regard. Humans get two sets of teeth in the course of their lives: milk teeth and “second teeth”. Ideally, these last until the end of life, but unfortunately this is not usually the case. Is the treatment of teeth no longer possible, they usually have to be removed. The patients are then dependent on dentures. The ability to grow third-generation teeth could change that. A drugwhich could make this possible, is currently the subject of research by Japanese scientists.
Left Right? Doctor pulls Wiener (18) the wrong tooth
A clinical trial is planned for July 2024, according to the national daily of Japan, “Mainichi”, recently reported. “The idea of growing new teeth is everyone’s dream dentistsaid Dr. Katsu Takahashi, principal investigator and head of the Department of Dentistry and Maxillofacial Surgery at the Medical Research Institute Kitano Hospital, who has been researching this development since about 2005.
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Genetic tooth development disorder
The innovative new drug helps treat people who have a rare disease genetic disorder not having a full set of adult teeth – called anodontia. Tooth germs are not created for either the deciduous teeth or the permanent teeth. If a few teeth are missing, this is called partial anodontia. People who grow up without teeth struggle with basic skills like chewing, swallowing and speaking from an early age, which can have a negative impact on their development.
Gene blocking as a solution
The researchers see the solution in the USAG-1 gene. The antibody for this gene, USAG-1, can help stimulate tooth growth when it’s suppressed – something Takahashi found in a Study published in Science Advances in 2021 further investigated. Since then, scientists have worked to develop a “neutralizing antibody drug” that can block USAG-1. In tests on mice and ferrets, the researchers found that the animals were able to grow new teeth.
available in 2030
After the drug has passed the necessary tests, the researchers hope to make it available for the treatment of children aged 2 to 6 who are showing signs of anodontia. The plan is for the drug to be available for public use by 2030. If successful, it will be the first drug in the world to allow patients to regrow teeth.
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