soon a probiotic to reinforce antibiotics?

This first phase 2 clinical trial (which aims to assess the possible dose of effectiveness of a remedy on a small number of patients before moving on to larger trials), was published in the journal The Lancet Microbe and reveals that probiotics containing live microorganisms can be a way to supplement or replace antibiotics.

A very useful probiotic in the face of growing antibiotic resistance

Staphylococcus aureus infection is the fourth leading cause of death in hospital in France and represents more than a quarter of nosocomial infections. This is a real concern at a time when resistance to antibiotics is growing day by day. While this bacterium causes serious infections of the skin, bones, lungs and blood, it is increasingly resistant to methicillin, the antibiotic most commonly used against it.

Viruses and infectious agents such as staphylococcus adapt, in fact, to the antibiotics usually used to counter them and “cunning”, which makes our usual antibiotics less and less effective. Therefore, there is an urgent need to find new weapons to fight the scourge of Staphylococcus aureus. For this, a team of researchers from the American public sector (National Institute of Health) decided to innovate by focusing on a probiotic, named Bacillus subtiliswhich reduced clearly » Colonization by Staphylococcus aureus among the participants. All without destabilizing the fragile balance of their intestinal microbiota.

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Less 97% Staphylococcus aureus after four weeks

After four weeks, the group of patients who had received this probiotic had 96.8% less Staphylococcus aureus in their stools (and less than 65% in their noses) than the control group who received a placebo.

Administered orally in the form of spores that manage to pass the stomach to develop temporarily in the intestine, the probiotic Bacillus is particularly promising because it would act as a sort of “hacking” Staphylococci aureus by disrupting their growth to better eliminate them. So, Bacillus is « tue “not Staphylococcus aureus but it” specifically and strongly decreases its ability to colonize “. A mechanism that also calls us to rethink what we thought we knew about the colonization of the body by Staphylococcus aureus.

These results make the researchers say that, even if it acts less quickly than antibiotics, this probiotic would be a means of reducing ” effectively » et « safely ” this plague.

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