Dr. Supakit Sirilak, Director-General of the Department of Medical Sciences Revealing the results of quality inspection of the smallpox vaccine (smallpox) that the Government Pharmaceutical Organization (GPO) has kept for more than 40 years, that now there is a smallpox vaccine that has been kept by the Government Pharmaceutical Organization (GPO) for more than 40 years, and Department of Science has brought to check the quality of vaccines. It is a live vaccine stored in a dry powder form at 2-8 ° C. Produced since 1979 and 1980, 13 production batches totaling 10,000 ampoules, containing 50 doses per tube, totaling 500,000 doses. The vaccine is the first generation vaccine. produced from animal saliva The form of application is by dripping into the skin and using a needle to scratch the skin to allow the vaccine to penetrate.
Dr. Supakit continued that the Institute of Biomass, Department of Science has inspected the quality of vaccines. The standard for laboratory vaccination includes physical examination. To determine the dry powder characteristics and solubility with the naked eye Chemistry-Physical Analysis Check the acidity – alkalinity. Security Analysis Analysis of pyrexin content and sterility The identity was checked by RT-PCR to confirm it was the smallpox virus. and check the strength To determine the effectiveness of the vaccine to determine whether the viral load is sufficient to induce immunity to prevent disease.
As for the results of the investigation, it was found that the 13 production batches of the smallpox vaccine still had good physical characteristics. It is acidic – alkaline. In the range of pH 7.38- 7.52 (general standard pH 6.0-8.0), the amount of febrifuge ranged between 4.20- 31.1 EU/ml (general standard, not more than 200 EU/ml). No microbial contamination was found. And the results of the uniqueness test revealed that it was a virus in the smallpox virus group. Orthopoxvirus and the vaccine has a potency between 6.42- 6.86 logTCID50/ml (World Health Organization standard Must be greater than or equal to 5.4 log TCID50/ml)
“In conclusion, 13 smallpox vaccines from the Government Pharmaceutical Organization are still of standard quality for general viral vaccines. and still have value If an outbreak occurs in the country and the smallpox vaccine is not available in a global outbreak situation The available smallpox vaccine could be used to prevent monkeypox. However, to be able to use it in an emergency situation will require cooperation from all parties involved in considering the benefits and risks and alternative vaccines available. Dr Supakit said