2023-07-12 18:47:16
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gut-brain axis: Describes a communication system that connects the gut and brain. The organs communicate via the nervous system, hormones and the immune system. Communication takes place in both directions: The brain sends signals to the gut and the gut also sends signals to the brain. These signals can affect digestion, eating behavior, stress levels, and overall mood.
An important component of the gut-brain axis are the trillions of microorganisms that live in the gut. Research suggests that Changes in the microbiome affect the gut-brain axis and potentially lead to health problems like irritable bowel syndrome, depression and even neurological diseases like Parkinson’s and Alzheimer’s.
lung-brain axis: Similar to the gut-brain axis, the lungs and brain also communicate with each other in both directions. The lungs can send signals to the brain through molecules, for example, while the brain has an influence on lung function and can help regulate inflammatory reactions in the lungs through the bronchial muscles.
Disorders in the lung-brain axis have been linked to a number of diseasesincluding asthma, chronic obstructive pulmonary disease (COPD) and neuropsychiatric disorders
In science, the possibility of a Liver-Brain Axis discussed. Researchers seem certain that there are also explicit communication channels between the two organs, through which information and signals are exchanged in both directions. The first studies show how exactly liver and brain health could be related.
First studies point to a connection between dementia and liver disease
Current research indicates a concrete connection between the liver-brain axis and the development of neurodegenerative diseases. In a study dated May 30, 2023 researchers from Spain examined the livers of mice known to have a genetic predisposition to the development of Alzheimer’s.
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It was found that mice with a predisposition to Alzheimer’s had liver dysfunction. Their livers were larger, suffered from greater oxidative stress and showed higher levels of inflammation. Via the exchange of signals between the liver and the brain, inflammatory molecules could cross the blood-brain barrier and have a negative impact on the brain.
In a other study from August 2022 researchers found a connection between fatty liver and cognitive disorders. At Overweight mice with fatty livers were more likely to exhibit depressive behaviors, lower oxygen levels in the brain, and altered cellular activity in the brain.
Further investigations must now follow and underpin the still young field of liver-brain axis research with data. Human studies also need to be done to confirm links between liver and brain health.
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