The mycobiota associated with cancer: enemy or ally?

Intratumoral mycobiota could weaken our immune system against tumors

After the craze of medical research on the gut microbiotaa true ally of our body in digestion and the immune system, two independent teams of researchers have focused their interest on thea fungal population of the flora around our cells: the mycobiota. And it would seem that she is instead the ally of a very dreaded cellular threat: the cancer. Indeed, the intratumoral mycobiota could weaken our immune system against tumours, allowing it to continue to colonize our organs.

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Some mushrooms (such as Candida albicans) would even set up an inflammatory environment favorable to tumor growth, and would help the migration of malignant cells to form metastases elsewhere. But one of the two teams sees this threat as an opportunity: the specific mycobiota of certain cancers would give a form of fungal signature to tumors, detectable in the blood, the stools or directly in the tissues. A very promising avenue for cancer screening.

Moreover, this dysbiosis could be a potential therapeutic target, through antifungal treatments, probiotics or even changes in diet, in combination with chemotherapy and immunotherapy, which would target cancer cells. The flora of our body has not finished talking about it…

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