2023-08-13 04:04:18
Text/Health Medical Network Zheng Yifen
With the disclosure of research on the importance of intestinal bacteria to human health, probiotics have aroused global experts’ discussions. Pan Ziming, an honorary professor of the Department of Biotechnology, Taiwan University, refined his lifelong research experience into a book “Pan Ziming Probiotics Health Research Laboratory: Scientifically Proving the Health Effects of Probiotics on 8 Major Diseases”, explaining that probiotics can improve neuropsychiatric and periodontal disease health care Important breakthroughs have been made in alleviating the side effects of osteoporosis and colorectal cancer chemotherapy, intestinal digestive health care, immune health care and the prevention of metabolic syndrome.
Figure / pixabay
The human gut contains 50 trillion microbes with a total weight of 1.5 kg, which is more than the 30 trillion human cells! The microorganisms in the intestinal tract are collectively referred to as “microbial flora”. In recent years, medical research has found that intestinal bacteria have a wide range of effects on health, whether it is inflammatory intestinal diseases, metabolic diseases, cardiovascular diseases, nerve-related diseases, immune diseases , and even mental-related diseases such as depression and anxiety are closely related to intestinal bacteria.
Important concepts of probiotics
Probiotics refer to a class of live microorganisms, including lactic acid bacteria, Bifidobacteria, yeasts, etc., when ingested in sufficient quantities, can have beneficial effects on the health of the user, including regulating intestinal flora, Promote the absorption of nutrients and regulate immunity, etc.
Generally speaking, there are normal microorganisms that coexist peacefully in the human intestinal tract. When their number and types decrease, they will be replaced by some pathogenic bacteria and cause dysbiosis, which in turn leads to many diseases and the death of Zhan people for many years Cancer with the highest rate is one of them.
There are good bacteria and bad bacteria in the intestinal tract. Specific bacteria will release endotoxin and other harmful molecules, leak into the blood through the intestinal wall, trigger the body’s “immune response”, cause “inflammation”, and cause damage to various systems in the body , in order to avoid the occurrence of diseases and even cancers, it is very important to maintain the “equilibrium” and “balance” of intestinal bacterial dynamics.
Modulating gut microbiota to improve disease occurrence
1. Gut Health:
Improve intestinal flora, constipation, diarrhea-type enteritis and prevent gastric mucosal damage
2. Immunomodulatory:
Improve immunity, ease allergic reactions, improve atopic dermatitis
3. Metabolic regulation:
Lower blood lipids, blood sugar, blood pressure and weight control
4. Slows Neuropsychiatric Degeneration:
Improve physical and mental memory decline such as stroke and dementia
5. To prevent cavities:
Reduce the adhesion and growth of cariogenic bacteria in the oral cavity
6. Periodontal care:
Reduce the number of periodontal disease-causing bacteria, improve alveolar bone loss and periodontal inflammation
7. Alleviate osteoporosis:
It can alleviate and prevent osteoporosis caused by estrogen deficiency after menopause
8. Relief of colorectal cancer chemotherapy side effects:
Inhibit cancer cell growth, improve anorexia and vomiting weakness
Animal experiments can alleviate the side effects of colorectal cancer chemotherapy
The World Health Organization predicts that the number of deaths due to cancer will increase to 70% of all deaths in the next 20 years. According to the statistics of the Ministry of Health and Welfare in 2021, colorectal cancer is the third cause of cancer death among Chinese people, and it is also the cancer with the highest incidence rate. Whether it is male or female, it ranks third in the death rate.
At present, the main method for the treatment of colorectal cancer is to give chemotherapy as an adjuvant after surgical resection of the tumor. However, chemotherapy often causes severe side effects in patients, such as anorexia, vomiting, weakness, and immunosuppression. Pan Ziming’s research team found from animal experiments that the combined use of NTU 101 fermented skim milk extract and chemotherapy drug 5-FU can enhance the effect of anticancer drugs on inhibiting the growth of cancer cells, and improve the weight loss and loss of appetite caused by chemotherapy drugs. Reduce tumor volume and reduce tumor metastasis in mice.
The ability of the active ingredients to inhibit the proliferation of cancer cells was evaluated in an in vitro colorectal cancer cell model. The results confirmed that the mixture of palmitic acid, stearic acid and glyceryl 1,3-dipalmitate contained in NTU 101 fermented skim milk As the main active ingredient, it can effectively reduce the concentration of chemotherapy drugs and enhance the effect of inhibiting cancer cell growth. At the same time, the related inhibitory mechanism has also been confirmed and published in Food Funct. (2019) 10: 7634-7644, the research results Selected as the cover image of the journal’s December 2019 issue.
Pan Ziming said that although probiotics are not a panacea, most scientists agree that probiotics can regulate the intestinal flora, promote the digestion, absorption and metabolism of nutrients in the intestinal tract, and benefit human health. In 2021, Taiwan’s health food produced with various raw materials will use lactic acid bacteria as the first raw material, with an annual output value of NT$6.1 billion. It is estimated that the global probiotics market will reach US$78.3 billion in 2026. Probiotics have evolved from traditional health care products to the latest next-generation probiotics, fecal flora transplantation, and exosomes that play a key role in precision medicine and regenerative medicine. The value of probiotics is also widely recognized Know.
【Extended reading】
This article is reproduced from “Health Medical Network”Expert research on maintaining intestinal balance: probiotics have health effects on 8 major diseases
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