The Story of Insulin: From Ancient Times to Modern Discoveries

2023-11-14 02:54:55

Today is World Diabetes Day. The International Diabetes Federation (IDF) has designated November 14th as the birthday of Dr. Frederick Banting in order to arouse the attention of various countries to the prevention and treatment of diabetes and commemorate the contribution of Dr. Frederick Banting to the discovery of insulin in 1921. It’s World Diabetes Day, so today let’s briefly talk about the story of insulin.

As early as more than 3,000 years ago, Egypt and Greek medical books more than 2,000 years ago both recorded a kind of patient: polyuria, weight loss, and death soon, which is similar to what is now known as type 1 diabetes (complete insulin deficiency type diabetes). Very similar.

What about the former Type 2? I think the progression of type 2 was very slow in the beginning and I didn’t know that I was sick. When I had three excesses and one deficiency (eating more, drinking more, urinating more, losing weight), in those days when I didn’t know what insulin was, I would make chicken essence ( (mistake), it is not surprising that they are all regarded as the first type.

It wasn’t until 1889, a good era when animal welfare groups did not exist, that two overly curious scientists, Baron Joseph Von Mering and Oskar Minkowski, wanted to know what the rotten pancreas was doing, so they took an unlucky little one and killed it. The dog’s pancreas was cut out and observed. Unfortunately, after a few days, it developed the same symptoms as people with type 1 diabetes. Curiosity can kill a dog.

Then in 1921, Frederick Banting, John James Rickard Macleod, Charles Best, Dr. James Bertram Collip and others collaborated to discover insulin. Because the discovery was so great and record-breaking, they won the Nobel Prize two years later. What was even greater was that they worked for Give up patents to save more patients in the world.

The answer “Diabetes is caused by insufficient insulin” makes human beings think that they have obtained a permanent pointer from Lafford, pointing to the One Piece to solve diabetes. At this time, human beings are boldly heading towards the great channel.

When I started further research on diabetes, I discovered a problem that hit me in the face in one second: Most people with early-stage, mild diabetes, not only do not have a lack of insulin in their bodies, but they actually have much higher levels?

Therefore, in 1988, Professor Gerald Reaven proposed the big devil behind “Syndrome

In recent years, Dr. DeFronzo has proposed eight major pathogenesis of diabetes (Ominous octet), step by step to complement the pathogenesis of diabetes. Is the puzzle complete? I don’t know, but what I do know is that the more complete the mechanism, the more comprehensive and perfect the disease can be treated.

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