Probiotic Akkermansia muciniphila seems to counteract Alzheimer’s
Numerous Probiotics are having positive effects on the Darmflora and the cognitive functions Applied. For the Akkermansia muciniphila probiotics a Chinese research team has now investigated to what extent such effects can actually be detected and whether the probiotic in Alzheimer could help alleviate the symptoms.
The connection between Darmmicrobial (Darmflora) and diseases of the brain has now been proven by numerous studies (see “Gut-Brain Axis: How Gut Bacteria Affect Brain and Behavior“). In addition, researchers from University Hospital Tübingen already proven that the Intestinal flora also linked to Alzheimer’s stands.
Influencing the gut microbiome as a therapy?
This suggested that a Influencing the gut microbiome a possible approach to Treatment of Alzheimer’s could represent. Whether probiotics can be helpful here, however, has so far remained open.
In the current study, a Chinese research team has now investigated the effect of the oral ingestion of Akkermansia muciniphila examined.
Cognitive impairments alleviated
The researchers assessed both the change in behavioral characteristics as well as Alzheimer-typical pathological changes in the organism of the animals. It turned out that the probiotic cognitive impairment of the rats and the deposition of Amyloid-beta 42 (Aβ42) in the brain relieved.
According to the researchers, the blood lipid levels (triglyceride, HDL cholesterol) and the liver values (AST/ALT levels) and the presence of some short-chain fatty acids (SCFA) that produce neurotransmitters increased. At the same time, the occurrence of some pathogenic intestinal bacteria associated with inflammation has decreased.
Action against Alzheimer’s pathologies
“Our results suggest that A. muciniphila has a remissive effect on Alzheimer’s-like pathologies”write the researchers in the journal “Experimental Gerontology“.
The effect may be about influencing the gut-brain axis triggered by the changed intestinal flora, but could also be caused by the influence on the peripheral circulatory metabolism.
Further studies required
To what extent the results can also be transferred to people with Alzheimer’s remains open for the time being. Further studies must now clarify whether taking Akkermansia muciniphila as a probiotic can alleviate Alzheimer’s symptoms in humans. (fp)
Author and source information
This text corresponds to the requirements of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Sources:
- Xiaoya Hea, Caixia Yan, Shuyang Zhao, Yuxi Zhao, Ruijie Huang, Yan Li: The preventive effects of probiotic Akkermansia muciniphila on D-galactose/AlCl3 mediated Alzheimer’s disease-like rats; in: Experimental Gerontology (veröffentlicht 21.09.2022), sciencedirect.com
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.