Interactions between bacteria and cancer cells
microorganismsthat inhabit the human body can ours Health affect to a large extent. The best example of this are gut bacteriatheir influence on our metabolism increasingly extensively documented. According to a recent study, microbes also seem to play a significant role in the course of certain cancers to play
researchers of Rutgers Cancer Institute of New Jersey identified certain microorganisms that multiplied in people with pancreatic tumors inflammation and worse survival rates are connected. The results were recently published in the journal “Cancer Cell” released.
What role do bacteria play in cancer?
Not only in our intestines, but also in other organs such as the lungs and the pancreas different microorganisms settle, which can influence the function of the organs.
As part of the current study, the Rutgers Cancer Institute working group checked whether microbes also course of cancer influence. To do this, the team analyzed whether bacteria are present in pancreatic tumors and whether they affect the progression of Krebs or have on treatment.
Pancreatic cancer is one of the most dangerous types of cancer
pancreatic cancer is relatively rare, but particularly aggressive. The chances of survival for those affected are among the lowest of all types of cancer. Due to the absence of symptoms in the early stages of the disease Tumors in the pancreas often discovered only after they have already begun to scatter.
Bacteria involved in the progression of pancreatic cancer
The researchers have succeeded in identifying specific microbes that are associated with a bad prognosis associated with pancreatic tumors.
The microorganisms represent a new and promising attackpoint that could influence the course of the disease. In addition, the bacteria could Early detection of pancreatic cancer be used.
RNA sequences evaluated
The team developed a new genomic approach that RNA sequences were evaluated. In this way it was possible to distinguish which sequences human and which microbial origin are.
“This new technique allowed us to identify tumor-associated microbes while simultaneously measuring host cell activity”explained Professor Dr. Subhajyoti Dewho along with Dr. Martin Blaser The lead author of the study is
Symbiosis between cancer cells and certain bacteria
With the new approach, the working group was able to determine that some bacteria were associated with certain cell types within the tumor that are not normally found in pancreatic tissue. Most of the bacteria discovered were found in the tumor cells.
The number of bacteria of this type present correlated with the activity of cancer cells. According to the research team, the signatures of the microbes found allow conclusions to be drawn about the expected course of pancreatic cancer.
New approaches to diagnosis and treatment of cancer
In addition, the researchers found that immune cells primarily react only to the bacteria, but not to the cancer cells associated with the bacteria.
“Our observations shed new light on why pancreatic cancer is so difficult to treat”stressed Dr. Blaser. According to him, a better understanding of the Interactions between bacteria and cancer cells show new therapeutic approaches against cancer. (vb)
Author and source information
This text corresponds to the requirements of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Author:
Graduate editor (FH) Volker Blasek
Sources:
- BasselGhaddar, Martin J. Blaser, Subhajyoti De, et al.: Tumor microbiome links cellular programs and immunity in pancreatic cancer; in: Cancer Cell (2022), cell.com
- Rutgers Cancer Institute of New Jersey: Researchers Find Tumor Microbiome Interactions May Identify New Approaches for Pancreatic Cancer Treatment (veröffentlicht: 10.10.2022), cinj.org
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.