“Improvement of renal fibrosis by inhibiting lactate-induced protein activity”
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(Seoul = Yonhap News) Reporter Choi In-young = The Korea Centers for Disease Control and Prevention (KCDC) announced on the 1st that a Korean research team discovered the cause of kidney disease, a major complication of diabetes, and opened the way for the treatment of diabetic kidney disease.
Dr. Wonho Kim’s research team at the National Institutes of Health, Korea Centers for Disease Control and Prevention (KCDC) found that the occurrence of lactic acidosis caused by excessive lactic acid production causes increased fibrosis and decreased glomerular filtration rate, which are indicators of renal dysfunction.
Accordingly, the research team explained that suppressing the expression of lactate-inducing protein A can improve the deterioration of renal function due to renal fibrosis caused by lactic acidosis.
This is the first study to show that lactic acidosis plays a role in reducing renal function due to renal fibrosis in patients with diabetic kidney disease.
The research team said, “We confirmed that lactic acid metabolites were directly secreted from patients with early diabetes, and that this was closely related to the occurrence of fibrosis through lactic acid increase in the kidney tissue of patients with diabetic kidney disease and decreased renal function.”
He added, “In the same diabetic kidney disease experiment, it was confirmed that abnormal lactate metabolism was the cause of renal tissue fibrosis and renal function deterioration.”
The results of this study, conducted using clinical information of Korean diabetic kidney disease patients, were published in the online edition of ‘Translational Research’, an international scientific journal in the field of clinical medicine, in August 2022.
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2022/09/01 10:05 Send