New Genes Associated with Breast Cancer: Insights from Groundbreaking Genetic Study

2023-08-23 06:17:12

Researchers have identified four new genes associated with breast cancer. The study was published in the journal Nature Genetics. Current genetic tests for breast cancer, led by researchers at the University of Cambridge in the UK and Université Laval in Canada, noted that only certain genes, such as BRCA1, BRCA2 and PALB2, are considered. The study suggests that more genes remain to be identified.

The latest study looked at genetic changes in all genes in 26,000 women with breast cancer and 217,000 women without breast cancer from eight countries in Europe and Asia. The researchers said this was possible using data from multiple studies in many countries and publicly available data from the UK Biobank.

‘This is the largest study of its kind to our knowledge…’ – said Professor Douglas Easton of the University of Cambridge, who led the study. The identification of these new genes will help to understand the genetic risk of breast cancer and help detect risk earlier by better identifying women at high risk, said Douglas Easton.

Most of the variants found in these new genes are rare, but women who carry them are at increased risk. For example, changes in one of the new genes, MAP3K1, are known to increase the risk of breast cancer in particular, the researchers said.

Causes and symptoms of breast cancer

Breast cancer is the most common cancer in women. Unhealthy diet, genetic factors, age, obesity and lifestyle are all factors that can lead to breast cancer. A clear understanding of the disease and its symptoms is essential for early detection of the disease.

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It is important to see a doctor if you notice symptoms such as breast lumps, changes in shape, enlargement of only one breast, reddening of the skin on the breasts, and thickening of the skin on the breasts.

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