Progestin Treatments and Meningioma Risk: Latest Discoveries and Prevention Measures

2024-03-28 09:05:47

Par

Published 5 hours ago, Updated 2 hours ago

Meningioma manifests itself with variable symptoms ranging from headaches to personality changes, including balance disorders and even epileptic seizures. LIGHTFIELD STUDIOS – stock.adobe

Certain progestin treatments increase the risk of meningioma, a tumor that is most often benign. Three new molecules have just been identified.

Mainly intended for women, progesterone derivatives are indicated in the treatment ofendometriosis, infertility but also as contraceptive means, in menstrual disorders or to accompany women towards menopause. However, since 2010, more than a thousand cases of meningiomas, a form of benign brain tumor, have been attributed to prolonged use of this type of treatment. Measures to restrict access to these molecules were put in place in France, while at the same time studies were carried out to measure the extent of the problem. The latest results appear this Thursday in the BMJ.

In this work carried out by EPI-PHARE, the scientific interest group made up of the ANSM and the National Health Insurance Fund (Cnam), an expert committee calculated the individual excess risk of around ten progestins, including those already incriminated (Androcur, Lutéran and Lutényl). They thus revealed that three additional molecules…

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