We all want to get rid of the excessFat, but body fat always seems to be stubborn. But this is only a superficial phenomenon. In fact, adipose tissue, like the organs in our body, is constantly metabolized and regenerated, and the life of fat cells is also limited. Eating the right food can “starve” dead fat cells.
Fatgrowth requires blood vessels to provide nutrients
At a microscopic level, adipose tissue is not only the white cellulite that we see with the naked eye, but also a huge number of capillaries running through it.
“Fat is like any other tissue—it needs a blood supply to stay alive.” Author of Eat to Beat Disease, President of the Angiogenesis Foundation, and former Harvard Medical School Dr. William Li, who teaches, said in an interview with The Epoch Times.
A normal person maintains a balance of fat in the body. “When fat grows in the body beyond its normal proportions, it results in excess adipose tissue, which requires more blood supply,” Li Weilin said.
Fat production is dependent on blood vessels.Specifically, if adipocytes continuously store lipids in lipid droplets, their size will gradually expand, and adipocytes will be deprived of oxygen, and this mild hypoxic state will allow the fat to release a series of and angiogenesis related factors that induce the formation of new blood vessels, which deliver oxygen and nutrients to cells and allow adipose tissue to grow[1]。
As fat builds up in the body, it’s not just the bones and muscles that put extra weight on, but the heart too. For every pound a person gains, about 5 miles of blood vessels are created to support the survival of these fat cells. Therefore, the heart has to pump blood more and farther.Faced with increasingly difficult tasks, a series of cardiovascular health problems will follow, such as increased blood pressure, increased heart disease rates, etc.[2]。
Excessive fat not only affects endocrine, but also damages organ function
And seemingly inert, inactive fat, in fact, the endocrine is very strong.
There are two types of fat in our body, white fat and brown fat. Li Weilin said that for the human body, brown fat is like a “heater” in a room; while white adipose tissue is not only an energy storage tissue, but also a major endocrine organ.
White fat secretes many hormones, including leptin, adipsin, angiotensinogen, adiponectin, resistin, etc., and also produces steroid hormones. These hormones affect energy homeostasis, glucose and lipid metabolism, vascular homeostasis, immune responses, and even fertility.When the mass of white fat changes significantly, almost everything secreted by it can be altered or even dysregulated[3]。
Additionally, when a person gets fatter, adipose tissue becomes dysfunctional due to lack of oxygen and inflammation, which releases large amounts of free fatty acids and adipokines into the bloodstream. These substances travel with the blood to other organs such as the liver, heart and large arteries, where they eventually accumulate in these tissues and change their properties and impair their function.
Therefore, controlling the white fat in the body at a reasonable level is very important for maintaining the health of the human body.
Stop blood vessel growth, control fat growth
Li Weilin made it clear in the interview that “laboratory studies have shown that preventing[excess]blood vessel growth can control fat growth.” He said this approach is the same as what is called “anti-angiogenesis,” which “has been used by It has been shown that cancer growth can be stopped by cutting off the blood supply and starving the cancer cells to death.” (Recommended reading:Many people have cancer cells!Eating these foods often starves cancer cells）
Many animal experiments have shown that the use of anti-angiogenic substances to inhibit and prevent the angiogenesis of fat cells can manage and treat high fat.dietobesity[4]。
The scientists treated mice that had become chubby after eating a high-calorie diet with an anti-angiogenic substance for 28 days. During the entire process, the mice were still fed a high-calorie diet. But it turned out that these otherwise obese mice lost about 30 percent of their body weight and lost an average of 15 grams each after receiving the anti-angiogenic substance, while the control group of mice did not receive the anti-angiogenic treatment and continued to gain weight.
Furthermore, the anti-angiogenic substances-treated mice had reduced postprandial blood glucose levels and insulin secretion levels.[5]。
The scientists further used monkeys to conduct experiments – spontaneously obese rhesus monkeys lost 7% to 15% of their body weight, 38% of body fat, and 27% of abdominal fat after 28 days of anti-angiogenic substance treatment. There was also a marked improvement in insulin resistance.
And scan images of its body show that the weight loss of rhesus monkeys is mainly achieved by reducing fat tissue, and there is no problem of fluid loss or muscle atrophy.[6]。
Eat these foods and starve fat cells
Many obese people may be looking forward to the launch of related drugs, and Li Weilin said: “The anti-angiogenesis therapy for fat is still in the research stage of drug development.” And he also emphasized in his book that new therapies are due to cost and availability. The problem is not necessarily available to everyone. Also, these drugs are designed to treat the disease, not prevent the problem.
But he also gave another convenient and feasible solution, which has been proven effective by many experiments, that is, eating “certain foods that contain substances that can inhibit angiogenesis.”
1. green tea
One of the foods that Li Weilin specifically mentioned isgreen tea。
During green tea processing, the tea leaves are heated to inactivate enzymes. The process of leaf shrinkage and drying prevents leaf autolysis and oxidation of components. The drying process of the tea leaves also contributes to the stabilization of the ingredients during storage.
Green tea is rich in a variety of catechins, and among them, epigallocatechin-3-gallate, referred to as EGCG (epigallocatechin-3-gallate) is the most abundant and active catechin in green tea. , accounting for 50% to 80% of the catechin content[7]。
For example, a cup of 250 ml of green tea brewed with 2.5 grams of tea leaves contains 240-320 mg of catechins, of which 60-65% is EGCG[8]。EGCG can down-regulate molecular signals related to angiogenesis and induce apoptosis, thereby playing an anti-angiogenic effect[9]。
EGCG catechin is effective against angiogenesis. In laboratory and human clinical studies, catechins have been shown to reduce fat growth.
A recent systematic review and meta-analysis showed that in more than 20 studies on green tea, people who drank green tea or supplements lost an average of 1.78 kg in body weight and an average of 0.65 kg/m² in body mass index.[10]。
In a controlled trial, postmenopausal women in the United States took green tea extract capsules (at doses of 400 or 800 mg of EGCG and a small amount of other catechins) per day for 2 months, compared with a placebo control group, took EGCG Significantly lower blood LDL cholesterol, glucose and insulin levels in these women[11]。
2. Tomato
Lycopene, which is rich in tomatoes, has anti-angiogenic effects, which is one of the reasons why it can effectively inhibit prostate cancer[12]. Lycopene at a concentration of 10 μM can significantly inhibit the angiogenesis of human umbilical vein endothelial cells, reduce angiogenesis branch points by 55%, and reduce vessel length by 40%[13]。
However, in order to obtain the protective effect of lycopene in tomato on the body, a healthydietmatch.Because experiments have found that the protective effect of lycopene is lost if a high-calorie diet is used to induce obesity.[14]。
Lycopene can promote metabolism and reduce body fat. A study between lycopene intake and metabolic disease in 374 middle-aged and elderly Dutch people showed that higher lycopene intake was associated with a lower risk of metabolic disease.Compared with those who consumed less lycopene, those who ate more lycopene in their diet had a 45% lower risk of developing metabolic disease, had less waist circumference and visceral and subcutaneous fat mass, and had less serum triglycerides content is also low[15]。
3. coffee
Li Weilin also mentioned foods containing chlorogenic acid, such ascoffee。
Experiments have shown that chlorogenic acid can inhibit the angiogenesis of human cells. When the concentration of chlorogenic acid is 25 μM and 50 μM, the inhibition rate of chlorogenic acid on the activity of epidermal growth factor reaches 10% and 18%, respectively.[16]。
In 150 overweight adults who drank coffee with 300 mg of chlorogenic acid per day for 12 weeks, visceral fat area, total abdominal fat area, body weight, and waist circumference were significantly reduced compared with those who drank coffee with lower chlorogenic acid content[17]。
In addition, Weilin Li recommends these foods: vegetables that contain sulforaphane, such as cabbage, broccoli, and kale; vegetables that contain quercetin, such as red onions; and foods that contain beta-glucans, such as mushrooms; and There is wakame with omega-3 fatty acids. In human studies, these foods have been shown to reduce body fat and improve metabolism. The Mediterranean diet also has a positive defense against angiogenesis.
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Responsible editor: Li Qingfeng