Coronavirus SARS-CoV-2
July 31, 2022 19:41 Robert Klatt
- A new vaccination patch can vaccines in Skin layers with high immune cell density inject
- In the Omikron-Variante des Coronaviruses was this vaccination method about 11 times more effective than ordinary needle vaccinations
- Also at other vaccines led the alternative vaccines to a stronger immune response
A new vaccine patch is 11 times more effective against the omicron variant of the coronavirus than the same vaccine given by needle.
Saint Lucia (Australia). Due to the Covid-19 pandemic, not only new ones have been created in recent years vaccines, but also explored alternative vaccination methods. Scientists at Hannover Medical School (MHH) have one Inhaled Covid-19 vaccine developed and at the University of North Carolina (UNC) a patch was created that Vaccination without injection allows.
Now researchers have the University of Queensland together with the biotechnology company Vaxxas another study was conducted using a vaccine patch. According to the publication in the specialist magazine Vaccine the Hexapro vaccine was administered using HD-MAP (High-Density Microarray Patch) technology. To put it simply, this system from Vaxxas is a Pavementthe vaccinations possible without an ordinary syringe.
Skin layers with high immune cell density
According to Christopher McMillan from the University of Queensland, the vaccine goes through the patch directly into an area of the body with a high number of immune cells. It is therefore useful in combating the omicron variant of the Coronavirus SARS-CoV-2 significantly more effective than ordinary needle vaccinations.
“The high-density microarray patch is a vaccine delivery platform that precisely delivers the vaccine to the layers of the skin that are rich in immune cells. We found that vaccination via a patch was approximately 11 times more effective at controlling the omicron variant than the same vaccine administered via a needle,” said McMillan
High effectiveness in all vaccines
In addition to the Hexapro vaccine, the scientists also studied other vaccines that they administered with the patch. The results were similar. “To date, every vaccine type we’ve tested with the patch, including subunits, DNA, inactivated viruses and conjugates, has elicited a superior immune response compared to traditional needle vaccination methods,” said McMillan.
Better immune response through vaccination patches
According to David Muller from the University of Queensland’s Faculty of Chemistry and Molecular Life Sciences, the study shows that alternative vaccination methods such as the vaccine patch significantly affect the immune response. In view of the currently approved vaccines and the ever-new virus variants, he says they are an opportunity in the fight against the Covid 19 pandemic.
“This reduced potency was demonstrated by the omicron variant, which contains over 30 mutations in the spike protein. The large number of mutations has given the virus the ability to evade the immune responses elicited by current vaccines,” explains Muller.
The tested patch technology has the potential, according to Muller, “to provide a new – and more effective – weapon in our arsenal at a time when new variants are mutating at a rapid pace.” In addition to the better effectiveness, the scientist also praises the simple application, which also enables laypersons to administer the vaccine.
Production plant already under construction
According to David Hoey, CEO of Vaxxas, his company’s vaccine patch “has game-changing potential to help nations better respond to global health emergencies such as the current and future pandemics.” The company is currently building its first production facility for the vaccine patch in Brisbane . Further clinical studies with significantly more test persons should also start in the near future.
Vaccine, doi: 10.1016/j.vaccine.2022.07.013