Professor Li Wanjun (left) and Dr. Xie Yida (right) from the Institute of Oral Biology of Yangming Jiaotong University researched “mitochondrial genes are expected to become markers of head and neck cancer”, which was successfully published in the journal “Cell Death and Disease”, and Selected as a monthly pick of the series. (Provided by Yangming Jiaotong University)
[Reporter Lin Xiaoyun/Taipei Report]Scientists are still understanding the reasons why normal cells become cancerous, which is different from the point of view of gene mutation. Professor Li Wanjun and Dr. Xie Yida of the Institute of Oral Biology, National Yangming Jiaotong University, from the perspective of cell metabolism, Studying the effect of “mitochondrial gene regulation” on the characteristics of “head and neck cancer cells”, we found the importance of abnormal mitochondrial physiology in cancer cells, so that mitochondrial genes are expected to become markers of head and neck cancer.
Yangming Jiaotong University released this news today. The research results have been published in the journal Cell Death and Disease and have been successfully selected as the monthly selection of this series of journals.
Please read on…
The research team found that compared with normal cells, the expression of mitochondrial transcription factors and their downstream genes in cancer cells is particularly low, which also increases the malignant degree of cancer cell growth, differentiation, metastasis, etc., confirming that cancer cells do not like mitochondrial genes. respiration.
Li Wanjun explained that mitochondria, known as cell power plants, are special organelles with DNA in cells. Mitochondrial transcription factors are used to regulate mitochondrial DNA. Scientists have found the reason why normal cells become cancerous from mitochondria. The clues confirm that mitochondrial transcription factors and mitochondrial DNA regulate the characteristics of cancer cells, so that mitochondrial gene molecules have the potential to become markers for detecting head and neck cancer.
Li Wanjun said that this study can confirm that the key to the survival of cancer cells lies in the metabolic adaptation to different environments. Normal cells obtain energy through mitochondrial respiration, but cancer cells do not like mitochondria, which indirectly confirms that cancer cells are in ” During the process of “deteriorating”, many different metabolic changes will be used to meet the challenges of harsh environments such as hypoxic environments and allow themselves to survive.
The research team used cells from common parts of head and neck cancer such as tongue, oral cavity and hypopharynx, combined with animal and clinical human head and neck cancer tissues, and obtained the conclusion that mitochondrial transcription factors and mtDNA were inversely related to cancer cell malignancy, confirming that mitochondrial transcription factors are inversely related to cancer cell malignancy. Factors are inhibitors of head and neck cancer, and drugs are currently under development to inhibit the ERK and Akt pathways. This study provides mitochondrial genomes as another predictor of head and neck cancer tumors.
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