The Los Angeles Chargers enter their Week 5 clash with the Denver Broncos at SoFi Stadium facing a daunting personnel crisis, as eight players missed Wednesday’s practice session entirely. With the team currently sitting at an 0-4 record, the latest injury report highlights a roster struggling to maintain depth across both the offensive and defensive lines.
Key Starters Sidelined Ahead of Sunday Kickoff
The injury report reveals significant concerns for the Chargers’ offensive front and secondary. According to the team’s official Wednesday disclosure, starting offensive tackles Joe Alt (neck) and Rashawn Slater (ankle) were among those who did not participate. Both players are currently expected to miss Sunday’s game, a development that complicates the team’s efforts to protect quarterback Justin Herbert.
The list of non-participants also includes wide receiver Ladd McConkey, who is managing a foot injury, as well as safety Derwin James Jr. (hamstring), cornerback Donte Jackson (hamstring), offensive lineman Trevor Penning (concussion), and guard Kayode Awosika (fibula). Khalil Mack also missed Wednesday’s session, though the team classified his absence as a veteran rest day.

Ten Players Return to Limited Practice
In addition to those sidelined, ten players were limited during Wednesday’s practice. This list features quarterback Trey Lance, who is dealing with a groin injury, along with wide receiver Quentin Johnston (chest) and defensive lineman Dalvin Tomlinson (hamstring). The team also monitored several players returning to the field; Branson Taylor (shoulder) and Scott Matlock (foot) were both limited as their 21-day practice windows officially opened this week.
Other players listed as limited participants include Brenen Thompson (quad), Cam Hart (knee), Alec Ingold (shoulder), Charlie Kolar (forearm), and Deane Leonard (rib). The cumulative impact of these injuries leaves the Chargers coaching staff with limited options as they prepare for the 1:05 p.m. PT kickoff against Denver.
Mounting Pressure on the Chargers’ Winless Start
The timing of these injuries could not be more difficult for a Chargers squad searching for its first victory of the season. The current injury-depleted lineup arrives as quarterback Justin Herbert attempts to find his rhythm following a challenging start to the season. The betting markets have responded to these roster uncertainties, with the Chargers currently listed as slight underdogs for the Week 5 matchup at SoFi Stadium.
As the team transitions toward the weekend, the status of the limited participants will be the primary indicator of the depth available for Sunday’s divisional contest. With 18 players total appearing on the injury report, the Chargers’ ability to field a competitive rotation remains the defining question for their upcoming meeting with the Broncos.