Today (9 May 65) the page of the Medical Genome Center, Ramathibodi Hospital, Mahidol University. Update on the genome-wide mutation of the 2019 coronavirus, the spiny-producing gene at the location “452” may be a factor in the omikron subspecies BA.4, BA.5, and BA.2.12. 1” that the World Health Organization (WHO) monitors have the ability to spread faster. It may also have the ability to connect cell walls (lungs) from multiple cells into a single cell. It can cause inflammation of the lung tissue, as is the case with past outbreaks of “delta” strains.
The entire genome of the 2019 novel coronavirus found a change in the thorn region at “452” from the amino acid “leucine (L)” to “arginine (R)” or “”. Glutamine (Q)” gives the spines properties that can connect neighboring cell walls. fused into a single cell As a result, the virus can rapidly spread cell-to-cell without leaving the cell, risking being captured and destroyed by “antibodies” created in the body of a previously infected naturally and by vaccination. The lung cells infected with the 2019 coronavirus are fused into a single cell. will become a large cell within a cell with multiple nuclei The DNA inside these cells is broken and broken. This makes the immune system of the infected person look foreign and destroys those multinucleated cells. inflammation And some people develop pneumonia, which can cause severe illnesses among the infected.
The “delta” strain has a thorn mutation to “R452” causing severe infections. This is partly due to pneumonia caused by the fusion of several infected cells into one cell. In contrast to the original omikron strains (B.1.1529) such as BA.1, BA.1.1 and BA.2, there were no mutations in these regions. The amino acid remains “L452”, consistent with the clinical manifestations of the original, mild omikron strain. One reason may be that syncytial pneumocytes are not formed in the infected lung cells.
But of concern is that both the omikron subspecies “BA.4” and “BA.5” that the WHO declared to be vigilant because of an outbreak in South Africa have mutated to R452, while the BA subspecies. 2.12.1 Outbreaks in the United States have mutated “Q452” back to the “delta” strain, potentially causing multiple infected cells to fuse into one (syncytial pneumocytes).
The spiny proteins of omikron subspecies BA.2 were more similar to substituents BA.2.12.1, BA.4, and BA.5 than substituents BA.1. Subtype BA.2 is likely to be more protective against infection with subspecies BA.2.12.1, BA.4, and BA.5 from subspecies BA.1 by both South Africa and the United States despite outbreaks of BA.2. The BA.1 subspecies was long followed by the BA.2 subspecies, yet the BA.4 and BA.5 subspecies are still endemic in South Africa. And subspecies BA.2.12.1 can spread in the United States. It suggests that mutations on the genome line of the BA.4, BA.5, and BA.2.12.1” subspecies at the “452” location are likely to be a key factor in promoting the spread.
Consequently, it is likely that substituents of omikron BA.4, BA.5, BA.2.12.1 may be more severely infected than the original omikron, and are being monitored by the WHO and scientists around the world. Clinical manifestations of closely related BA.4, BA.5 and BA.2.12.1 infections from South Africa and the United States. Because the breeding at position 452 is like a delta species. It is expected that clinical outcomes from local infected people will be known in the next 2-4 weeks. The latest update shows that the number of patients requiring hospitalization in the two countries has begun to increase. But the death rate remains the same.
Therefore, the vaccine should be vaccinated if it has not been vaccinated and the booster needle will be administered when it is due to prevent re-infection if an outbreak of omicron subspecies BA.4, BA.5 and BA.2.12.1 enters Thailand. This is because natural immunity from the original omicron strain or from the last dose of vaccine administered more than four months may be very effective in protecting us from less emerging subspecies of omicron.
Prof. Alex Cigal, a virologist at the African Institute of Health Research in South Africa. A person who has discovered the 2019 coronavirus, a beta strain And omicron substituents BA.4 and BA.5 indicate that laboratory tests have shown that vaccination and booster needles after infection have significantly reduced morbidity and mortality. statistically It also produces hybrid immunity, which is a wider range of immunity. Not specific to species that are immune stimulants only. This kind of “hybrid immunity” is better able to fight the newly emerged omikron species.