Blood lipid profiles indicate the development of neuropathy
A special Patterns of blood lipid profiles can be as early as ten years before the emergence of diabetic neuropathy, a nerve damage that often occurs in diabetes, indicate a disturbance in a signaling pathway that ultimately leads to the neuropathy. Exercise and a healthy diet help keep the nervous system healthy.
In a retrospective cohort study involving experts from University of Michigan lipidomic profiles were examined ten years before the diagnosis of neuropathy in people with type 2 diabetes.
The results were published in the English-language journal “Annals of Clinical and Translational Neurology“ published.
Analyzed serum samples from participants
The researchers analyzed the Serum samples from 69 participantsincluding 17 men and 52 women, which at Typ-2-Diabetes were ill. These individuals were examined for signs of neuropathy ten years later.
All in all 435 different types of lipids the researchers took into account. Lipids denote organic compounds that consist of fats and oils.
The team linked participants who showed changes in their lipids to diabetic neuropathies fest.
Impaired energy metabolism associated with neuropathy
According to the researchers, the changes in the lipids indicate that there is a problem disturbed energy metabolism to the persons concerned. This could be the forecast an increased risk of developing neuropathies.
„We have the potential to test these lipid biomarkers in patients with type 2 diabetes to identify those at highest risk of developing peripheral neuropathy and to enable more targeted treatment of these patients“, explained Study author Dr. Eva L. Feldman in a press release.
Test enables early prediction of neuropathy risk
The team managed to identify a pattern in the blood lipid profiles of the participants, which signal interference in a critical signaling pathway that indicates the label b-Oxidation carries. According to the experts, this signal disturbance can be detected ten years before the development of a neuropathy.
According to the researchers, the identified metabolic pathway changes Lipids in sources of energy for the nerves around. However, if this metabolic pathway is disrupted, this leads to the low-energy nerves are damaged. The result is neuropathy.
„As we learn more about the relationship between serum lipids and neuropathy, it opens the possibility of targeted therapeutic treatment, both with drugs and lifestyle interventions“, explained Dr. Feldman.
Unsaturated fats for healthy nerves
According to the doctor, study results also support the critical view of saturated fats and the recommendation of unsaturated fats if better source of energy for the nerves.
Die mediterranean diet According to the expert, it is particularly suitable for strengthening the nervous system, with sufficient movement should be respected. because dr According to Feldman exercise increases the efficiency of the identified b-oxidation pathway.
Thus are movement and a healthy one nutrition the key to protecting yourself from diabetic neuropathy. (as)
Author and source information
This text corresponds to the requirements of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Sources:
- Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, et al.: Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes; in: Annals of Clinical and Translational Neurology (veröffentlicht 03.08.2022), Annals of Clinical and Translational Neurology
- University of Michigan: Lipid Profile Predicts Nerve Damage Risk In Type 2 Diabetes (veröffentlicht 29.09.2022), University of Michigan
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.