2024-03-24 23:03:05
IT·Science
Entered2024.03.25 08:03 Modified2024.03.25 08:03
U.S. research team “High-fat diet suppresses expression of inflammation-related proteins… induces intestinal-liver-brain inflammation”
In experiments using mice, it was revealed that a high-fat diet inhibits the expression of inflammation-regulating proteins, causing an inflammatory response that extends from the intestines to the liver and then to the brain, causing diabetes and Alzheimer’s-like symptoms. Professor Narendra Kumar’s team at Texas A&M University in College Station, USA, confirmed this fact in mouse experiments at the annual meeting of the American Society for Biochemistry and Molecular Biology (Discover BMB) held in San Antonio from the 23rd to the 26th, and said that this could cause Alzheimer’s disease in diabetic patients. It was revealed that the molecular level mechanism is present.
There is increasing research showing a link between type 2 diabetes and Alzheimer’s disease, and some scientists are even calling Alzheimer’s disease ‘type 3 diabetes.’
Additionally, diabetes and Alzheimer’s disease are both considered the fastest growing health problems worldwide. Professor Kumar said, “I believe that diabetes and Alzheimer’s disease are closely related. Taking measures to prevent or improve diabetes can prevent or at least significantly slow the progression of dementia symptoms in Alzheimer’s disease.”
The research team explained that diet has a significant impact on the development of diabetes and health. In this study, they tracked how specific proteins in the intestines affected the brain through mouse experiments to determine the effect of diet on the development of Alzheimer’s disease in diabetic patients. .
First, we investigated the effect on the expression of Jak3, one of the enzymes that regulate immunity and inflammation, in high-fat diet mice, and created a mouse model deficient in Jak3 in the whole body or some tissues through genetic manipulation. The impact was confirmed. As a result of the analysis, it was found that the expression of Jak3 was suppressed in mice that ate a high-fat diet, and that mice lacking this protein developed a series of inflammation that started in the intestines, passed through the liver, and continued to the brain.
In addition, these mice were found to show symptoms similar to Alzheimer’s disease, such as excessive expression of beta-amyloid (Aβ) and hyperphosphorylated tau (τ) protein in the brain, which are known to cause dementia, and also showed cognitive impairment.
Professor Kumar said, “In this study, we confirmed that food affects the expression of Jak3, leading to leaky gut syndrome, which ultimately leads to chronic inflammation, diabetes, a decrease in the brain’s ability to eliminate toxic substances, and Alzheimer’s disease-like symptoms.” “It continues,” he said. “The good news is that you can block these inflammatory pathways by controlling your blood sugar levels with a healthy diet,” he said. “Managing diabetes through lifestyle changes during pre-diabetes can prevent the progression of diabetes and reduce the risk of Alzheimer’s disease.” .
/yunhap news
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