Unlocking the Benefits of Taiwanese Lemon: Regulating Depression and Anxiety Through the Gut-Brain Axis

2023-08-23 02:00:49

There are many benefits of lemon!Xingda University’s latest research on adjustable depression and anxiety published in international journals

Bergamot has anti-obesity, anti-oxidation, anti-inflammation, and liver-protecting activities, and has been widely developed as a health food in Japan. According to the research and development team led by Wang Shengyang, Dean of the School of Circular Economics, National Chung Hsing University, it was found that Taiwanese lemon can regulate the symptoms of depression and anxiety induced by chronic mild stress through the “gut-brain axis”. This result was published in the UK in August An important academic journal “Food and Function” published by the Royal Society of Chemistry.

Returning to Taiwan from Japanese red lemons can reduce three highs and fight obesity

Taiwan bergamot is a species native to Taiwan. Its scientific name is “Bianshi lemon”. It is distributed in low-altitude areas of Taiwan and Ryukyu in southern Japan. Most of the citrus plants in the domestic market are exotic species. Among the 3 species of citrus plants native to Taiwan, Taiwan bergamot has the most economic value and development potential. In addition to the fruit can be processed into a variety of food, because It has good anti-obesity, anti-oxidation, anti-inflammation and liver protection activities, and has been widely developed as a health food in Japan.

The aroma of Taiwanese bergamot is mainly composed of limonene, terpinene and linalool. In addition to the special flavor, bergamot juice is rich in nobiletin and tangeretin. These two flavonoids have been proven to have diverse health functions, such as reducing hyperlipidemia, hyperglycemia, high blood pressure, obesity and other related diseases. Metabolic risk factors, also proven to improve brain degenerative diseases, such as Parkinkin’s disease. At the same time, nobiletin and tangeretin have also been found to have regulating activity on the problem of three highs, and have a good inhibitory effect on gout. Also due to the remarkable anti-inflammatory effect of nobiletin, it has a soothing effect on various arthritis such as gouty arthritis and osteoarthritis.

Through the “brain-gut axis”, bergamot helps regulate symptoms of depression and anxiety

The “brain-gut axis” refers to the two-way regulatory network of the central nervous system of the brain and the digestive function of the intestinal tract, involving many physiological mechanisms, including the immune system, endocrine system, central nervous system, autonomic nervous system in the peripheral nervous system, and cranial nerves. System and enteric nervous system and gut flora.

Among them, the intestinal flora not only participates in the nutrient absorption of digested matter, regulates the development of intestinal and nerve cells, but also induces the development of the immune system. More and more studies have pointed out that the imbalance of intestinal flora may cause anxiety, depression, autism, Parkinson’s disease and other mental diseases, as well as cancer, autoimmune diseases, and even chronic diseases such as obesity and diabetes.

With the financial support of the National Science Council and the Ministry of Agriculture, Xingda’s research team conducted research and development on the components and activities of domestic Taiwanese bergamot, and obtained specific results. Wang Shengyang explained that from the “Anxiety and Depression Model Induced by Random Chronic Mild Stress in Mice”, it was found that no matter whether the mice were sniffed or tube-fed Taiwan lemon, they could significantly improve the symptoms of decreased gastrointestinal digestion and absorption function caused by chronic stress. Phenomenon. And the anxiety, depression, and obsessive-compulsive behaviors of mice under stress can effectively improve the performance of depression behaviors after being treated with Taiwan lemon, and can well regulate the central nervous system activity. According to the analysis results of the bacterial phase of the next-generation sequencing, it can be known that tube feeding or smelling the aroma of Taiwan bergamot fruit can improve the imbalance of bacterial phase caused by chronic stress.

Interestingly, Taiwan bergamot also increased the proportion of beneficial bacteria Bacteroidetes and decreased the proportion of bad bacteria Firmicutes in the gastrointestinal tract. In addition, it can reduce the proportion of Clostridium species associated with autism and increase the proportion of Tremorella species. As mentioned above, Taiwanese lemon has various health functions, and long-term use will greatly benefit the physical and mental health.

At present, the School of Circular Economics and the Department of Food and Applied Biotechnology are working together to develop lemon drinks and smelling essential oils. Wang Shengyang said that drinking it for a day can help restore normal intestinal flora, improve anxiety and depression, and help sleep. Moreover, not only the juice is drinkable, but also the peel can be ground into essential oil and animal feed. The peel is rich in 4 kinds of flavonoids, so bergamot can be said to be a very high-quality plant that can be used from the fruit to the peel.

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